11th International Conference on Biology and Synchrotron Radiation (BSR)

M. Wilmanns, D. Svergun

Grand Elysée Hotel Hamburg, Germany

Sunday 8 September - Wednesday 11 September 2013

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Final Programme

 

Day 1 - Sunday, 8 September 2013
TimeSpeaker 
14:00-16:00 Registration/snacks  
16:00-17:00 Opening words  
16:15-17:00

Keynote Lecture
Jochen R. Schneider, CFEL, DESY Hamburg, Germany

Structural Biology at Accelerator Laboratories: 40 Years of development and many more to come

 
17:00-19:30

Session 1 - Synchrotron Instrumentation
Chairs: Stefan Fiedler, EMBL Hamburg, Germany
Robert F. Fischetti, Argonne National Laboratory, USA

17:00-17:30

Gwyndaf Evans, Diamond Light Source Ltd, United Kingdom

Microbeams for Macromolecular Crystallography at Diamond Light Source

 
17:30-18:00 Naoto Yagi, SPring-8/JASRI, Japan

Time-resolved Small-Angle Scattering Experiments in Sub-millisecond Range

18:00-18:30

Adrian Mancuso, European XFEL, Hamburg, Germany

The Single Particles, Clusters and Biomolecules (SPB) Instrument of the European XFEL

 
18:30-18:50 Selected Talk

Daniele de Sanctis, European Synchrotron Radiation Facility, France
Automation and robotics at ESRF Structural Biology beamlines

 
18:50-19:10

Selected Talk

Jianhua He, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China
Macromolecular Crystallography Beamlines at SSRF

 
19:10- 19:30

Selected Talk

Masaki Yamamoto, RIKEN SPring-8 Center, Japan
The micro-beam beamline at SPring-8 open protein micro-crystallography

 
19:30-21:00 Get together  

 

 
Day 2 - Monday 9 September 2013
TimeSpeaker 
08:30-10:30 Session 2 - Biological sample preparation and characterization
Chairs: Rob Meijers, EMBL Hamburg, Germany
Yvonne Jones , University of Oxford, United Kingdom
08:30-09:00 Imre Berger, EMBL Grenoble, France

Complexomics - Expanding the research tool-box for multiprotein complexes

 
09:00-09:30 Susanne Gräslund, University of Toronto, Canada

Production of human proteins for structural genomics and generation of affinity reagents

 
09:30-09:50 Selected talk

Melissa Graewert, EMBL Hamburg, Germany
An in-line biophysical characterization and purification set-up at the P12 SAXS beamline of the EMBL-Hamburg

 
09:50-10:10 Selected talk

Pie Huda, University of Copenhagen, Denmark
Development of the Nanodisc for Small-angle Scattering Based Structural Studies of Membrane Proteins

 
10:10-10:30 Selected talk

Manfred Roessle, Luebeck University of Applied Science, Germany
SAXS-CD a microfluidic high throughput screening platform for solution scattering

 
10:30-11:00 Coffee Break  
11:00-13:00 Session 3 - Biological small angle X-ray scattering

Chairs: Jill Trewhella, The University of Sydney, Australia;
Dmitri Svergun, EMBL Hamburg, Germany

11:00-11:30

Clement Blanchet, EMBL Hamburg, Germany

Brilliant solution SAXS for high throughput and challenging tasks

 
11:30-12:00 Lois Pollack, Cornell University, USA

SAXS and nucleic acids: stories of structural dynamics, ion association and condensation

 
12:00-12:20 Selected talk

Georg Schulz, University of Basel, Switzerland
Myelin abundance and orientation in a non-stained slice of human brain

 
12:20-12:40 Selected talk

Patrice Vachette, IBBMC, France
Conformation in solution of Smac/DIABLO and of its complex with XIAP-BIR2BIR3

 
12:40-13:00 Selected talk

Bente Vestergaard, University of Copenhagen, Denmark
SAXS data reveal significant changes at the interface between solvent and protein fibril surface: Potential implications for the fibrillation mechanism

 
13:00-14:30

Lunch

Industry presentation sessions

13:15- 13:45 Dectris

Exploiting high speed data acquisition with PILATUS3 - Marcus Müller - Dectris

13:45 – 14:15 Incoatec/Bruker
Incoatec - your Partner for X-ray Optics and Microfocus Sources - Jörg Wiesmann
Synchrotron Instrumentation from Insertion Devices to Experimental Stations - Wolfgang Diete

 
14:30-16:30 Poster Session I  
16:30-18:40

Session 4 - Macromolecular X-ray crystallography
Chairs: Sean McSweeney, European Synchrotron Radiation Facility, France
Thomas R. Schneider, EMBL Hamburg, Germany

16:30-17:00 Piet Gros, Utrecht University, The Netherlands

Complex formation and conformational changes in the complement system

 
17:00-17:30

Andrew Thompson, Synchrotron SOLEIL, France

The facilities for macromolecular crystallography at SOLEIL

 
17:30-18:00 Marjolein Thunnissen, Lund University, Sweden

MX at MAX IV

 
18:00-18:20 Selected talk

Kazuya Hasegawa, SPring-8/JASRI, Japan
The upgrade project of the high flux macromolecular crystallography beamline BL41XU at SPring-8

 
18:20-18:40

Selected talk

Vladimir Popov, Bach Institute of Biochemistry RAS, Russian Federation
Enzymes from extremophilic microorganisms: structural insight into molecular basis of extremophilicity

 
19:00-22:30

Optional tour to INCOATEC – free registration by e-mail

 
 
 
Day 3 - Tuesday 10 September 2013
TimeSpeaker 
08:30-10:30 Session 5 - Biological X-ray imaging, and absorption

Chairs: Britt Hedman, SLAC, Stanford University, USA
Carolyn Larabell, UCSF, USA

This session is sponsored by Synchrotron SOLEIL

08:30-09:00 Leann Tilley, University of Melbourne, Australia

Cryo transmission and coherent diffraction x-ray imaging of the malaria parasite, Plasmodium falciparum

 
09:00-09:30 Lisa M. Miller, Brookhaven National Laboratory, USA

Using X-ray Spectroscopic Microscopy to Image Metal Ions and their Role in Alzheimer’s Disease Pathology and Diagnosis

 
09:30-09:50 Selected talk

Ana Diaz, Paul Scherrer Institut, Switzerland
Cryo-imaging of frozen hydrated cells with hard x-ray nanotomography

 
09:50-10:10 Selected talk

Masato Hoshino, Japan Synchrotron Radiation Research Institute, Japan
Measurement of density map in fresh biological sample using X-ray phase contrast tomography

 
10:10-10:30

Selected talk

Carolyn Larabell, University of California, San Francisco, USA
Soft x-ray tomography of the cell nucleus

 
10:30-11:00 Coffee Break  
11:00-13:00 Session 6 - Applications to medically relevant objects

Chairs: Jean Doucet, University of Paris, France
Stephen Kevin Burley, Rutgers University, USA

11:00-11:30 Pamela Williams, Astex Pharmaceuticals, United Kingdom

From fragment to candidate: the advantages of structural certainty

 
11:30-12:00

K.R. Rajashankar, NE-CAT, USA

Attaining optimum exposure time with dose-sliced data collection

 
12:00-12:20

Selected talk

Jean Doucet, NOVITOM, France
How synchrotron imaging techniques can unveil the internal structure of tablet coatings

 
12:20-12:40

Selected talk

Sylvain Bohic, INSERM, France
Synchrotron X-ray fluorescence micro and nanoprobe a useful tool in neurosciences

 
12:40-13:00

Selected talk

Nathan Cowieson, Australian Synchrotron, Australia
bioSAXS as a direct assay of medically relevant protein activity

 
13:00-14:30

Lunch

Industry presentation session

13:10 – 13:30 Xenocs
High brilliance clean beam and low background for SAXS studies of protein solutions - Nicoleta Galatanu
13:30 – 13:50 Rigaku 
13:50 – 14:10 DESY 
14:10 – 14:25 XTal Concepts

 
14:30-16:30 Session 7 - Sources and methods development

Chairs: James Holton, University of California, Berkeley, USA;
Sol M. Gruner, Cornell University, USA

14:30-15:00

James Holton, University of California, Berkeley, USA

The structure of disorder

 
15:00-15:30

Bauke W. Dijkstra, European Synchrotron Radiation Facility, France

The ESRF Phase 2 upgrade plan: opportunities for biology

 
15:30-15:50 Selected talk

Daniel Franke, EMBL Hamburg, Germany
Predicting the Folding State of Proteins in Solution from Small Angle X-Ray Scattering Data

 
15:50-16:10 Selected talk

Ivan Vartaniants, DESY, Germany
Diffract from many get one –X-ray cross correlation analysis of SAXS coherent diffraction patterns

 
16:10-16:30 Selected talk

Joel L. Sussman, Weizmann Institute of Science, Israel
Proteopedia - a Scientific 'Wiki' Bridging the Rift Between 3D Structure and Function of Biomacromolecules

 
16:30-19:30 Visit to DESY  
19:30-22:30 BBQ Party – DESY campus  

 

 
Day 4 - Wednesday 11 September 2013
TimeSpeaker 
08:30-10:30

Session 8 - Structural biology hybrid applications
Chairs: Matthias Wilmanns, EMBL Hamburg, Germany;
Soichi Wakatsuki, SLAC, Stanford University,

08:30-09:00

Junichi Takagi, Institute for Protein Research, Osaka University, Japan

Analyzing higher-order architecture of synaptic adhesion machinery: correlation technologies to fill the gap between different imaging methods

09:00-09:15

Selected talk

Jose de Pereda, Instituto de Biología Molecular y Celular del Cáncer (CSIC-USAL), Spain
Structure of a fragment of the integrin ß4 by hybrid methods: x-ray crystallography, small angle x-ray scattering and electron paramagnetic resonance spectroscopy

 
09:15-09:30

Selected talk

Thomas Monecke, Georg-August-University Göttingen, Germany
A hybrid methods approach unveils the structural basis for the cooperativity of CRM1 nuclear export complex formation

 
09:30-09:45

Selected talk

Savvas Savvides, Ghent University, Belgium
Cooperative assemblies of oncogenic receptor tyrosine kinases revealed by hybrid methods in structural biology

 
09:45-10:00

Selected talk

Spyros Chatziefthimiou, EMBL Hamburg, Germany
A hybrid approach to structural and functional characterisation of the sarcomeric protein myomesin

 
10:00-10:15

Selected talk

Ivo Tews , University of Southampton, UK
Extending the knowledge on eukaryotic vitamin B6 biosynthesis

 
10:15-10:30

Selected talk

Jens Morth, Oslo University, Norway
Crystal structure of PacL a bacterial P-type ATPase

10:30-11:00 Coffee Break  
11:00-13:00 Poster Session II  
13:00-14:30 Lunch  
14:30- 17:30 Session 9 - Free Electron Laser applications in biology 

Chairs: Victor Lamzin, EMBL Hamburg, Germany;
Keith O. Hodgson, SLAC, Stanford University,, USA

14:30-15:00

Janos Hajdu, Uppsala University, Sweden and The European XFEL, Hamburg, Germay

Diffraction from single macromolecules

15:00-15:30

Henry Chapman, CFEL DESY, Germany

Structure determination with X-ray FEL pulses

 
15:30-16:00 Keith O. Hodgson, SLAC, Stanford University, United States of America

Recent Developments at SLAC and Stanford in Biocrystallography Using LCLS

 
16:00-16:20

Selected talk

Charlotte Uetrecht, European XFEL Facility GmbH, Germany
How to deliver single Biomolecules to X-ray Free-Electron Lasers with high structural and dynamic Resolution?

 
16:20-16:40

Selected talk

Sebastien Boutet, SLAC, Stanford University, USA
Multiplexing the FEL Beam for Increased Structural Biology Capacity at LCLS

 
16:40-17:00

Selected talk

Thomas White, CFEL, Germany
CrystFEL: analysis software for serial femtosecond crystallography

 
17:00-17:30 Closing remarks and poster prize